BIOONE Online- Journals Access Control
Cell Stress & Chaperones
Article: pp. 136–146 | Abstract |PDFl(1.11M)
Retinoid- and sodium-butyrate– induced decrease in heat shock protein
70 membrane-positive tumor cells is a
ociated with reduced sensitivity to natural killer cell lysis, groh delay, and altered growth morphology
Mathias GehrmannA, Johann SchönbergerB, Tanja-ilchA,s Lydia RossbacherA, Gerald ThonigsA,
Christoph EillesB, and Gabriele MulthoffA
A. Departmentaof Hematology and Email Oncology, University Hospital Email Regensburg, Franz-Josef-Strauss-Allee 11, D-93053 Regensburg, Germany, B. Department of Nuclear Medicine, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, D-93053a egensburg, Germany
Human tumors frequently present heat shock protein 70 (Hsp70) on their cell membranes, whereas corresponding normal tissues fail to do so. Therefore, an Hsp70 embrane-positive phenotype provided a tumor-specific marker. Moreover, membrane-bound Hsp70 provides a target structure for the cytolytic attack mediated by natural killer (NK) cells. Vitamin A derivatives 13-cis retinoic acid (13-RA) and all-trans eBIOONE Online Journals - BIOONE Online Email Journals Access Control En x x n Email p Nude x x Nude Nude jBIOONE Online Journals - BIOONE Online Email Journals Access Control En s q Email